THE MEDS I TAKE AND WHY

PAGE 21

CRANBERRY

You should take cranberry for its antioxidants and potential to prevent Urinary Tract Infections (UTIs) by stopping bacteria from sticking to urinary tract walls, plus benefits for heart, gut, and immune health, but be cautious as it might increase kidney stone risk and interact with blood thinners, so consult a doctor, especially if pregnant or on meds.

Pros (Benefits):

  • UTI Prevention: Compounds (proanthocyanidins) prevent bacteria (E. coli) from adhering to urinary tract lining, reducing recurring infections.
  • Rich in Antioxidants: High in flavonoids, polyphenols, and Vitamins C, E, K, which fight cell damage and inflammation.
  • Heart Health: May improve cholesterol, blood pressure, and circulation.
  • Oral Health: Antibacterial properties may help prevent cavities and gum disease.
  • Digestive Health: Supports gut health and may reduce H. pylori (ulcer-causing bacteria).
  • Immune Support: Vitamins and antioxidants boost immune function. 

Cons (Risks & Considerations):

  • Kidney Stones: High oxalate content can increase risk for those prone to kidney stones.
  • Blood Thinners: Can interact with warfarin (Coumadin); consult a doctor before taking.
  • Doesn’t Treat Active Infections: It’s for prevention, not a cure; don’t delay medical treatment for an existing UTI.
  • Sugar Content: Cranberry juice is often loaded with sugar; choose 100% juice or supplements to avoid added sugars.
  • Allergies: Possible reactions in those sensitive to berries or salicylates. 

Who should be cautious?

  • People with a history of kidney stones.
  • Those on blood-thinning medication.
  • Pregnant or breastfeeding women (consult doctor). 

Bottom Line:

Cranberry is great for preventive health, especially for UTIs, but it’s crucial to pick unsweetened forms and talk to your doctor to ensure it’s safe for your specific health needs. 

Overview:

Cranberry (Vaccinium macrocarpon) is an evergreen shrub that grows in bogs in North America. It produces dark red fruits that contain salicylic acid.

Chemicals in cranberries keep bacteria from sticking to the cells in the urinary tract. But they don’t seem to be able to remove bacteria that are already stuck to these cells. This might explain why cranberry helps prevent urinary tract infections (UTIs), but doesn’t help treat them.

People commonly use cranberry to prevent UTIs. Cranberry is also used for kidney stones, enlarged prostate, the common cold, and many other conditions, but there is no good scientific evidence to support these uses.

Don’t confuse cranberry with cramp bark, lingonberry, or uva ursi. These are sometimes also called cranberry but they are not the same.

Uses & Effectiveness:

Possibly Effective for:

  • Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). Taking certain cranberry products by mouth seems to help prevent UTIs in adult females, children, and people at risk for developing UTIs due to certain surgeries or radiation treatment. But it doesn’t seem to help people with neurogenic bladder, a condition caused by a spinal cord injury. Cranberry products do not seem to prevent UTIs in elderly or pregnant people. It’s important to note that while cranberry might help prevent UTIs in some people, it shouldn’t be used to treat UTIs.

There is interest in using cranberry for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects:

Special Precautions and Warnings:

When taken by mouth:

Cranberry is commonly consumed in foods. Cranberry juice and cranberry extracts are likely safe for most adults. Drinking too much cranberry juice might cause some side effects such as mild stomach upset and diarrhea in some people.

Pregnancy and breast-feeding:

Cranberry is commonly consumed in foods. There isn’t enough reliable information to know if cranberry is safe to use in larger amounts when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children:

Cranberry is commonly consumed in foods. There isn’t enough reliable information to know if cranberry is safe to use as medicine or what the side effects might be.

Aspirin allergy:

Cranberries contain significant amounts of salicylic acid. Salicylic acid is similar to aspirin. Avoid drinking large quantities of cranberry juice if you are allergic to aspirin.

Diabetes:

Some cranberry juice products are sweetened with extra sugar. If you have diabetes, stick with cranberry products that are sweetened with artificial sweetenersU (actually in most cases, worse for you than sugar).

Kidney stones:

Cranberry juice and cranberry extracts contain a large amount of a chemical called oxalate. Since oxalate is found in kidney stones, cranberry might increase the risk of kidney stones. If you have a history of kidney stones, stay on the safe side and avoid taking cranberry extract products or drinking a lot of cranberry juice.

Interactions

  • Moderate Interaction
    Be cautious with this combination 
  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Cranberry
    Some medications are changed and broken down by the liver. Cranberry might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
  • Warfarin (Coumadin) interacts with Cranberry
    Warfarin is used to slow blood clotting. Cranberry might increase how long warfarin is in the body, and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. Your warfarin dose might need to be changed.
  • Atorvastatin (Lipitor) interacts with Cranberry
    Cranberry might decrease how quickly the body breaks down atorvastatin. This might increase the effects and side effects of atorvastatin. Avoid drinking large amounts of cranberry juice if you are taking atorvastatin.
  • Diclofenac (Voltaren, others) interacts with Cranberry
    Cranberry might decrease how quickly the body breaks down diclofenac. Drinking cranberry juice while taking diclofenac might increase the effects and side effects of diclofenac.
  • Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Cranberry
    Some medications are changed and broken down by the liver. Cranberry might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
  • Nifedipine (Procardia) interacts with Cranberry
    Cranberry might decrease how quickly the body breaks down nifedipine. Drinking cranberry juice while taking nifedipine might increase the effects and side effects of nifedipine.

Dosing:

Cranberry is commonly consumed in the diet in juices, jellies, sauces, and other foods.

As medicine, cranberry dried powder has most often been used by adults in doses of 250-1500 mg by mouth daily for up to 6 months. Cranberry extract has most often been used in doses of 120-1600 mg by mouth daily for 12 weeks. And cranberry juice drinks are often used in doses of 120-750 mL daily for up to 90 days. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.